• brenucsb twitter avatar
    Covering Crops: How federal crop insurances\ program reforms can reduce costs, empower farmers, an protect natural… https://t.co/DcUnk6dvvE
    1 hour 56 min ago
  • ucsantabarbara twitter avatar
    This #GauchoAlum assists families in finding the right match in staffing for their domestic needs with her company… https://t.co/nxDyExIUlR
    4 hours 51 min ago
  • UCSBgauchos twitter avatar
    Late 12-0 Run Propels UCSB Past UC Irvine, 70-58 https://t.co/m2qU0XrYQS
    14 hours 20 min ago
  • UCSBgauchos twitter avatar
    Behind a career-high 24 kills from Corey Chavers, UCSB men's volleyball topped No. 10 Pepperdine 3-1 Saturday night… https://t.co/D5nsniMX9v
    17 hours 37 min ago
  • UCSBgauchos twitter avatar
    Gauchos Defeat USC for First Time Since 1994 With 6-1 Win https://t.co/Qx2MIg8mlk
    17 hours 53 min ago
  • UCSBgauchos twitter avatar
    UCSB Swim Earn Double Win Against Pacific https://t.co/5HIEA1jVrZ
    18 hours 37 min ago
  • UCSBgauchos twitter avatar
    https://t.co/TZEXKzXVyd https://t.co/RBJFqndgNu
    18 hours 48 min ago
  • UCSBgauchos twitter avatar
    Gauchos Topple Cal Baptist; Fall to Michigan on Second Day of Winter Invitational https://t.co/q5hTJ946Cy
    18 hours 51 min ago
  • UCSBgauchos twitter avatar
    Gauchos Top Long Beach on the Road for First Time since 2010-11 https://t.co/LmjZSo4XSU
    18 hours 54 min ago
  • UCSBgauchos twitter avatar
    https://t.co/SxjQYEoij3 https://t.co/9FACb1DuV5
    18 hours 54 min ago
  • UCSBgauchos twitter avatar
    @UCSBbasketball tonight at 9pm st the Thunderdome vs. UC Irvine. ESPN and free t-shirts. Students get in free!
    20 hours 44 min ago
  • UCSBgauchos twitter avatar
    Tune in here: https://t.co/9h2e8ItJlN to see @UCSBWWP take on Michigan at Campus Pool at 5pm! #UCSB #gogauchos
    21 hours 54 min ago
  • brenucsb twitter avatar
    About 1/3 of all food made for people is wasted. This study shows how using #aquaculture by-products that are typic… https://t.co/YuoXomoFqA
    23 hours 41 min ago

Teaming Up Against Sepsis

UCSB scientists collaborate with multiple institutions to conduct biomedical research on sepsis, thanks to a $12.8 million grant
Tuesday, July 19, 2016 - 10:00
Santa Barbara, CA

Blood born infection.png

Venn diagram

Venn diagram portraying relationships, including infection, bacteremia, sepsis and the Systemic Inflammatory Response Syndrome.

Photo Credit: 

Steven Burdette

Jamey Marth.jpg

Jamey Marth

Jamey Marth

Michael Mahan.jpg

Michael Mahan

Michael Mahan

A multidisciplinary team of scientists — including two UC Santa Barbara faculty members — is poised to undertake a major biomedical research initiative focused on the escalating problem of sepsis, the body’s abnormal response to severe infections.

Jamey Marth, director of UCSB’s Center for Nanomedicine (CNM) and also a professor of the Sanford Burnham Prebys Medical Discovery Institute (SBP) in La Jolla, has been awarded a five-year, $12.8 million research grant from the National Institutes of Health (NIH). Increasingly rare, these large awards are structured to fund the best multi-investigator programs using a team approach to solving an important biological and medical problem.

“We were delighted to learn that the NIH reviewed our application as having ‘high potential to radically change the way we understand and treat sepsis,’” said Marth, who is also UCSB’s Carbon Professor of Biochemistry and Molecular Biology and the Mellichamp Professor of Systems Biology. “Millions of people are diagnosed with sepsis each year worldwide, and on average 30 percent die from the complications of sepsis. No new effective treatments have been developed in decades.”

Marth’s team includes CNM-associated scientists and clinicians from multiple institutes, including UCSB, SBP, Santa Barbara Cottage Hospital and UC San Diego.

“I am excited by what this team and unique research program can do,” said co-investigator Michael Mahan, a professor in UCSB’s Department of Molecular, Cellular, and Developmental Biology, with expertise in infectious disease. “Sepsis is an increasing human health problem, and this award represents a large investment made toward solving it. In fact, to my knowledge, this is the largest NIH research grant ever awarded to a UCSB faculty member.” 

Marth added: “This award also indicates that UCSB can effectively compete for scarce NIH biomedical research funds, even without a medical school. The grant leverages the multidisciplinary and synergistic expertise of scientists from multiple institutions and provides access to SBP’s technological and administrative resources.”

Playing a lead role in the translational component is Dr. Jeffrey Fried, an acute care physician at Cottage Health and an expert in the diagnosis and treatment of human sepsis. Fried and Marth have collaborated over the past four years.

“With Dr. Fried’s expertise, we have already made unexpected discoveries pertaining to human sepsis,” Marth said. “This productive, long-term collaboration with Fried was seen by NIH and the review panel as a significant strength of our application.”

“While we have made great strides at Santa Barbara Cottage Hospital in reducing the mortality of sepsis by two-thirds over the past 11 years, we have reached a plateau of what we can accomplish without new treatments,” Fried explained. “Marth and his co-investigators have done seminal work in investigating the molecular basis of sepsis. This work should translate into the development of radically different and more effective approaches to treating sepsis in the future.”

Additional contributing biomedical scientists and clinicians include UCSD faculty member Jeffrey Esko, an expert in the mechanisms of blood-based diseases, and Dr. Dzung Le, head of the clinical hematology and coagulation laboratory at UCSD’s Hillcrest and Thornton hospitals. SBP’s Jeffrey Smith brings leading expertise in mass spectrometry methods applied to blood systems in health and disease to the research effort. 

The program will also benefit from the involvement of renowned scientists and clinicians who are members of participating institutions’ advisory boards. “Sepsis remains the leading killer of patients in intensive care units and there are no approved medications,” said advisory board member Dr. Victor Nizet, chief of the Division of Host-Microbe Systems and Therapeutics at UCSD’s School of Medicine. “The highly innovative discoveries by Jamey Marth and his team have inspired a rethinking of how blood components respond to severe infection and suggest new ways to restore normal function and protect vital organs from injury.”

Marth noted the program’s potential to reduce the frequency of disability and death in patients diagnosed with sepsis. “We have an extraordinary opportunity to achieve major advances in the understanding and treatment of sepsis,” he said.

Contact Info: 

Julie Cohen
(805) 893-7220