• UCSBgauchos twitter avatar
    WWP: Gauchos End The Day With A Dominate Win And A Close Loss https://t.co/U0mHxrjEPb
    3 hours 5 min ago
  • UCSBgauchos twitter avatar
    WBB: Gauchos Share The Cape In All-Around 74-62 Win Over Hawai'i On Super Hero Night https://t.co/7JozUy4Wi1
    4 hours 26 min ago
  • UCSBgauchos twitter avatar
    Vincent Hits 1,000 Point Mark But UCSB Loses at UC Riverside, 65-55 https://t.co/rvtR2CFZwU
    5 hours 18 min ago
  • ArtsandLectures twitter avatar
    Tune in to @prairie_home to hear @odonovanaoife & pals performing songs from #lalaland! Now on KCLU
    6 hours 2 min ago
  • UCSBgauchos twitter avatar
    WBB: FINAL UCSB 74 - Hawaii 62 Gauchos rack up season-best 4th straight win, improve to 9-9 (4-1). Edelman 19pts 6reb, Toler 17pts off bench
    6 hours 24 min ago
  • UCSBgauchos twitter avatar
    WBB: We're inside the last minute of regulation, Toler with 10 points in the final quarter. 71-60 UCSB 46.1 remaining.
    6 hours 30 min ago
  • UCSBgauchos twitter avatar
    WBB: Gauchos roar off the first 8pts and Hawaii needs to talk about it! 58-45 UCSB 7:54 remaining in the fourth quarter.
    6 hours 46 min ago
  • UCSBgauchos twitter avatar
    WBB: End of Third Quarter UCSB 50 - Hawaii 45 Hernandez goes for 8pts in 3Q. Gaucho pep band is ready for the fourt… https://t.co/VDP5Er1MZ1
    6 hours 53 min ago
  • UCSBgauchos twitter avatar
    WBB: Gauchos respond to a mini Hawaii run with a Durr and-one, and back-to-back 3's from Hernandez. 45-37 UCSB 4:56 left in 3Q.
    7 hours 3 min ago
  • UCSBgauchos twitter avatar
    WBB: Halftime UCSB 31 - Hawaii 26 Edelman with team highs 10pts and 3rebs. Gauchos a 14-8 pts in paint advantage, 11-2 off turnovers.
    7 hours 26 min ago
  • UCSBgauchos twitter avatar
    WBB: Toler with an emphatic chase down block from behind! She has first 2 buckets for UCSB in 2Q. 27-19 Gauchos, 4:21 before halftime.
    7 hours 37 min ago
  • UCSBgauchos twitter avatar
    WBB: End of First Quarter UCSB 23 - Hawaii 15. Porter leads all scorers with 9pts, 3/4 from downtown. Gauchos 11pts from 5 Hawaii turnovers.
    7 hours 47 min ago
  • UCSBgauchos twitter avatar
    WBB: Gauchos sink their first 4 from the field, 3/3 from downtown and lead 18-9 at 1Q media break. Porter 2/2 for trey, Edelman doing work.
    7 hours 53 min ago
  • brenucsb twitter avatar
    Growing an interest in nature: #UCSB students & Edible Campus Project plant seeds of sustainability in preschoolers https://t.co/dyoiFtroWo
    13 hours 36 min ago
  • UCSBgauchos twitter avatar
    Gauchos Travel to No. 7 UCLA https://t.co/JPxd6rq7Qt
    1 day 4 hours ago

UCSB Chemists Make Discovery that May Lead to Drug Treatment Possibilities for Alzheimer's, Diabetes, and other Diseases

Thursday, February 10, 2011 - 16:00
Santa Barbara, CA

2427-1.jpg

Michael T. Bowers

Michael T. Bowers

UC Santa Barbara scientists have made a discovery that has the potential for use in the early diagnosis and eventual treatment of plaque-related diseases such as Alzheimer's disease and Type 2 diabetes. Their work is published in a recent issue of Nature Chemistry.

The amyloid diseases are characterized by plaque that aggregates into toxic agents that interact with cellular machinery, explained Michael T. Bowers, lead author and professor in the Department of Chemistry and Biochemistry. Other amyloid diseases include Parkinson's disease, Huntington's disease, and atherosclerosis. Amyloid plaques are protein fibrils that, in the case of Alzheimer's disease, develop prior to the appearance of symptoms.

"The systems we use are model systems, but the results are groundbreaking," said Bowers. He explained that his research provides the first examples of the conversion of randomly assembled aggregates of small peptides into ordered beta sheets that comprise fibrils. Fibrils are the final structural state of the aggregation process.

In the article, Bowers describes how understanding the fundamental forces that relate aggregation, shape, and biochemistry of soluble peptide aggregates is central to developing diagnostic and therapeutic strategies for amyloid diseases.

Bowers and his research team used a method called ion-mobility spectrometry-mass spectrometry (IMS-MS). This method enabled the team to deduce the peptide self-assembly method. They then examined a series of amyloid-forming peptides clipped from larger peptides or proteins associated with disease.

Bowers explained that IMS-MS has the potential to open new avenues for investigating the pathogenic mechanisms of amyloid diseases, their early diagnosis and eventual treatment.

The first author of the paper is Christian Blieholder, a Humbolt Postdoctoral Fellow at UCSB. Thomas Wyttenbach, UCSB associate researcher, is a co-author. Nicholas F. Dupuis, who was a Ph.D. student at UCSB at the time of the research, is also a co-author; he is now a postdoctoral fellow at the University of Colorado.

The Bowers Group