• ucsantabarbara twitter avatar
    From theory to practice, this week's #GauchoCourse prepares soon-to-be professors for the real world. https://t.co/DAj0nUIwAw
    2 hours 5 min ago
  • UCSBgauchos twitter avatar
    MVB: Gauchos snap 7 match losing streak with emphatic sweep of UCSD on Friday night. RECAP >>>… https://t.co/Cee1KbeXOh
    11 hours 56 min ago
  • UCSBgauchos twitter avatar
    Women's Tennis: UC Santa Barb. 2, Oregon 5 (Final)
    14 hours 24 min ago
  • UCSBgauchos twitter avatar
    WBB: Gauchos Face First-Place UC Davis Looking to End Two-Game Skid https://t.co/wRGTYxtxDC
    15 hours 25 min ago
  • ucsantabarbara twitter avatar
    Called “tama” or “tamashii,” the belief in spirits of deceased ancestors goes back centuries. https://t.co/KUJg2oGc7k
    15 hours 50 min ago
  • UCSBgauchos twitter avatar
    Muno (2 H, 2 R), Corey (3-4, 2 R), Davis (7 IP, 2 ER, 10 K) lead @UCSB_Baseball to 7-4 win in home opener! RECAP >>… https://t.co/I32qmDSuZB
    16 hours 18 min ago
  • ArtsandLectures twitter avatar
    Fascinating! #Sapiens + #HomoDeus author #YuvalNoahHarari predicts humankind’s future: https://t.co/5P25xtpyRQ via… https://t.co/TIAzFchgfI
    16 hours 50 min ago
  • ArtsandLectures twitter avatar
    RT @AshleyyySb: Only on Twitter to continue to absorb all insight and research from @DrSidMukherjee || Stoked to attend his lecture @Artsan
    17 hours 5 min ago
  • brenucsb twitter avatar
    Does location affect how pines react to climate change? Bren PhD student Ian McCullough shares answer #BrenPhDTalks https://t.co/6zVyQetm2t
    17 hours 10 min ago
  • UCSBgauchos twitter avatar
    Softball: Fifth-Inning Dooms Gauchos in 6-4 Loss to Purdue https://t.co/XWYKVl9UPx
    17 hours 12 min ago
  • UCSB_GradPost twitter avatar
    Register for 2017 Graduate Division Commencement before May 5! https://t.co/IDP1WGLGik #UCSB #ucsbgradpost
    17 hours 19 min ago
  • brenucsb twitter avatar
    Bren PhD student Jessica Perkins' research answers: "What Makes an #LCA Study Influential?" https://t.co/HatfwVTKV4 #BrenPhDTalks
    17 hours 20 min ago
  • brenucsb twitter avatar
    Runsheng Song shares strategies to estimate chemicals' life cycle inventories with little data #BrenPhDTalks https://t.co/gUsRney8nC #LCI
    17 hours 30 min ago
  • brenucsb twitter avatar
    #BrenPhDTalks: Bren PhD student Ying Wang looks at nanomaterial accumulation in soybeans & nitrogen-fixing bacteria https://t.co/85xiy6EmAY
    17 hours 40 min ago
  • brenucsb twitter avatar
    Bren PhD student Yuwei Qin uses US potato production to show how to model marginal production in #LCA https://t.co/jDyW0Fkzbx #BrenPhDTalks
    17 hours 50 min ago

UCSB Researchers Develop Drug Delivery System Using Nanoparticles and Lasers

Wednesday, September 9, 2009 - 17:00
Santa Barbara, CA

Researchers at UC Santa Barbara have developed a new way to deliver drugs into cancer cells by exposing them briefly to a non-harmful laser. Their results are published in a recent article in ACS NANO, a journal of the American Chemical Society.

"This entirely novel tool will allow biologists to investigate how genes function by providing them with temporal and spatial control over when a gene is turned on or off," explained Norbert Reich, senior author and a professor in the Department of Chemistry and Biochemistry at UCSB. "In a nutshell, what we describe is the ability to control genes in cells –– and we are working on doing this in animals –– simply by briefly exposing them to a non-harmful laser."

The scientists used cancer cells from mice, and grew them in culture. They then introduced gold nanoshells, with a peptide-lipid coating, that encapsulated "silencing ribonucleic acid" (siRNA), which was the drug that was taken up by the cells. Next, they exposed the cells to a non-harmful infrared laser.

"A major technical hurdle is how to combine multiple biochemical components into a compact nanoparticle which may be taken up by cells and exist stably until the release is desired," said Gary Braun, first author and a graduate student in UCSB's Department of Chemistry and Biochemistry. "Laser-controlled release is a convenient and powerful tool, allowing precise dosing of particular cells within a group. The use of biologically friendly tissue penetration with near-infrared light is the ideal for extending this capability into larger biological systems such as tissues and animals."

The authors demonstrated, for the first time, the delivery of a potent siRNA cargo inside mammalian cancer cells, released by exposing the internalized nanoparticles for several seconds to a pulsed near-infrared laser tuned for peak absorption with a specific spatial pattern. The technique can be expanded to deliver numerous drug molecules against diverse biological targets.

The additional collaborating authors on the paper are Alessia Pallaoro, also of UCSB's Department of Chemistry and Biochemistry; Guohui Wu and Joseph A. Zasadzinski, of UCSB's Department of Chemical Engineering; Dimitris Missirlis, of UCSB's College of Engineering, and Matthew Tirrell, former dean of UCSB's College of Engineering and now at UC Berkeley.

 

 


 

 

[RETURN TO TOP]  

 

Top photo: The near-infrared laser pathway into the cell culture plate, traced by visible laser for photo.
photo credit: Rod Rolle

†† Bottom photo: Gary Braun uses cancer cell cultures and a pulsed laser to study remote control gene silencing by specialized nanoparticles. The normally invisible laser is replaced by a visible one for the photo.
photocomposite credit: Rod Rolle

Norbert Reich