• ArtsandLectures twitter avatar
    Watch pianist #MurrayPerahia's breathtaking and imaginative performance, tonight at 7PM at UCSB Campbell Hall!… https://t.co/M83EeA6Y53
    2 hours 30 min ago
  • UCSBgauchos twitter avatar
    Softball: Hawai'i Tops UCSB 5-1 in Gauchos' Final Road Series Opener https://t.co/ejf0MWM1g0
    9 hours 51 min ago
  • UCSBgauchos twitter avatar
    Gauchos Sweep Past UCI 4-0 https://t.co/WFwbxDV8eA
    12 hours 28 min ago
  • ucsantabarbara twitter avatar
    We're happy to see you back, alumni! Don't miss the great events we have this weekend. #AllGauchoReunion… https://t.co/Sbz4iirr7i
    16 hours 5 min ago
  • UCSBgauchos twitter avatar
    Women's Tennis: Cal Poly 0, UC Santa Barb. 4 (Final) No.2 UCSB blanks No.7 Cal Poly in Big West Quarterfinal 4-0 https://t.co/m4kdACQFo5
    16 hours 8 min ago
  • UCSBgauchos twitter avatar
    .@UCSB_Baseball vs. UC Riverside on @ESPN3 is live now! Watch here >>> https://t.co/QJMvNLa0mQ
    16 hours 27 min ago
  • UCSBgauchos twitter avatar
    WWP: Defending Big West Champs Defeated by No. 12 LBSU in Another Overtime Match https://t.co/XIO3RJdo9p
    16 hours 45 min ago
  • UCSBgauchos twitter avatar
    Top-Seeded UCSB Set to Host Big West Golf Championship at Sandpiper GC https://t.co/SyXPKB2Ur5
    18 hours 20 min ago
  • UCSBLibrary twitter avatar
    RT @ForestSways: CEMA poster preservation for primary source research. #Chicanohertiage @Marikhasmanyan @UCSBLibrary #sca17 https://t.co/M…
    20 hours 21 min ago
  • UCSBLibrary twitter avatar
    @AmldavisAnn We're glad you're interested in using, please contact (805) 893-3062 or @library.ucsb.edu">special@library.ucsb.edu for m… https://t.co/fwAVOMoWyB
    20 hours 22 min ago
  • UCSB_GradPost twitter avatar
    CPT F-1 Visa workshop for international students on May 11 https://t.co/l6xZEndRVl #UCSB #ucsbgradpost
    20 hours 37 min ago
  • UCSB_GradPost twitter avatar
    Two open postdoc positions on Verification of Quantum Cryptography https://t.co/ZRA2iro7Ym #UCSB #ucsbgradpost
    20 hours 38 min ago
  • UCSB_GradPost twitter avatar
    Professor Micaela J. Díaz-Sánchez to speak about bomba on May 2 https://t.co/D4g84xVXkD #UCSB #ucsbgradpost
    20 hours 38 min ago
  • ArtsandLectures twitter avatar
    #DavidSedaris talks to the @SBIndpndnt about his new book Theft By Finding: "You might say he’s stolen our hearts."… https://t.co/fR3WFw02CL
    21 hours 32 min ago
  • brenucsb twitter avatar
    Is it possible to have negative GHG emissions? #UK launches national initiative to find negative emissions tech https://t.co/gHHHQHJLf1
    21 hours 34 min ago

UCSB Researchers Develop Drug Delivery System Using Nanoparticles and Lasers

Wednesday, September 9, 2009 - 17:00
Santa Barbara, CA

Researchers at UC Santa Barbara have developed a new way to deliver drugs into cancer cells by exposing them briefly to a non-harmful laser. Their results are published in a recent article in ACS NANO, a journal of the American Chemical Society.

"This entirely novel tool will allow biologists to investigate how genes function by providing them with temporal and spatial control over when a gene is turned on or off," explained Norbert Reich, senior author and a professor in the Department of Chemistry and Biochemistry at UCSB. "In a nutshell, what we describe is the ability to control genes in cells –– and we are working on doing this in animals –– simply by briefly exposing them to a non-harmful laser."

The scientists used cancer cells from mice, and grew them in culture. They then introduced gold nanoshells, with a peptide-lipid coating, that encapsulated "silencing ribonucleic acid" (siRNA), which was the drug that was taken up by the cells. Next, they exposed the cells to a non-harmful infrared laser.

"A major technical hurdle is how to combine multiple biochemical components into a compact nanoparticle which may be taken up by cells and exist stably until the release is desired," said Gary Braun, first author and a graduate student in UCSB's Department of Chemistry and Biochemistry. "Laser-controlled release is a convenient and powerful tool, allowing precise dosing of particular cells within a group. The use of biologically friendly tissue penetration with near-infrared light is the ideal for extending this capability into larger biological systems such as tissues and animals."

The authors demonstrated, for the first time, the delivery of a potent siRNA cargo inside mammalian cancer cells, released by exposing the internalized nanoparticles for several seconds to a pulsed near-infrared laser tuned for peak absorption with a specific spatial pattern. The technique can be expanded to deliver numerous drug molecules against diverse biological targets.

The additional collaborating authors on the paper are Alessia Pallaoro, also of UCSB's Department of Chemistry and Biochemistry; Guohui Wu and Joseph A. Zasadzinski, of UCSB's Department of Chemical Engineering; Dimitris Missirlis, of UCSB's College of Engineering, and Matthew Tirrell, former dean of UCSB's College of Engineering and now at UC Berkeley.

 

 


 

 

[RETURN TO TOP]  

 

Top photo: The near-infrared laser pathway into the cell culture plate, traced by visible laser for photo.
photo credit: Rod Rolle

†† Bottom photo: Gary Braun uses cancer cell cultures and a pulsed laser to study remote control gene silencing by specialized nanoparticles. The normally invisible laser is replaced by a visible one for the photo.
photocomposite credit: Rod Rolle

Norbert Reich