• UCSB_GradPost twitter avatar
    Writing, literature, and classics fellowship opportunities with… https://t.co/bHYZqcwGX5 #UCSB #ucsbgradpost
    56 min 35 sec ago
  • brenucsb twitter avatar
    .@UCSB research published in @nature shows correlation between #climate & distribution of #soil acidity https://t.co/1DgKnFufCz
    6 hours 27 min ago
  • UCSB_GradPost twitter avatar
    Pre- and postdoctoral fellowships for research on Africa and African… https://t.co/pLtjHGcvHi #UCSB #ucsbgradpost
    23 hours 55 min ago
  • UCSB_GradPost twitter avatar
    Earth science postdoc opportunity at National Science Foundation https://t.co/npbqvcJgEb #UCSB #ucsbgradpost
    1 day 2 hours ago
  • UCSB_GradPost twitter avatar
    Postdoc fellowships in physical sciences, astronomy, and atmospheric… https://t.co/k80YIzjNgD #UCSB #ucsbgradpost
    1 day 2 hours ago
  • brenucsb twitter avatar
    Join #BrenUCSB Frank Davis Monday for a “Science Pub” talk titled “A Plant’s-eye View of Climate Change in Californ… https://t.co/FhvXUTf6UC
    1 day 4 hours ago

UCSB Scientists Discover Potential Drug Delivery System

Monday, August 24, 2009 - 17:00
Santa Barbara, CA

imagetn.aspx_.jpg

Tambet Teesalu and Kazuki N. Sugahara

Photo Credit: 

Rod Rolle

Scientists at UC Santa Barbara have discovered a potential new drug delivery system. The finding is a biological mechanism for delivery of nanoparticles into tissue. The results are published in this week's Proceedings of the National Academy of Sciences.

"This work is important because when giving a drug to a patient, it circulates in the blood stream, but often doesn't get into the tissue," said senior author Erkki Ruoslahti, of the Burnham Institute for Medical Research at UCSB. "This is especially true with tumors.

"We believe this method will lead to better, more efficient delivery of drugs," he said. In this study, the scientists used prostate cancer cells as their target, but the method could apply to any type of cell.

The scientists developed a peptide, a small piece of protein that can carry "cargo" for delivery into the cell. The cargo could be a nanoparticle, or even a cell. Riding on the peptide, the cargo gets out of the blood vessel and penetrates the tissue.

The drug is located at one end of the peptide. At the other is the "C terminal," which has the "motif" –– an amino acid sequence including arginine or lysine, that causes the tissue penetration. This terminal has to be open, the researchers found. The strict requirement for the C terminal led the group to coin a new name, the "C-end rule," or CendR, pronounced "sender."

Ruoslahti explained that another exciting aspect of the study is the discovery that viruses appear to use this "CendR" system to get into cells. "It's a natural system," he said. "We're not quite clear what the exact function is, but viruses appear to take advantage of it."

Ongoing research in the Ruoslahti lab is understanding how viruses use this system, and then working to develop inhibitors to prevent viruses from entering the cell.

The two first authors on the paper are Tambet Teesalu and Kazuki N. Sugahara, both of the Burnham Institute for Medical Research at UCSB. Third author Venkata Ramana Kotamraju, of the same institute, made the peptides. Ruoslahti is also affiliated with the Burnham Institute for Medical Research in La Jolla, Calif.